G. Cornejo, A. Pikarsky, P. Blumenfeld, M. Wygoda, J. Feldman, A. Hubert,L. Appelbaum-Pikarsky, A. Khalaila,A. Imam, G. Zamir
Introduction
• The prognosis following surgery for pancreatic cancer remains poor, local recurrence is common and negatively impacts the survival rate.
• To improve local control and potentially improve survival, we have adopted a strategy of adding intra-operative electron radiation therapy (IOeRT) to selected patients undergoing pancreatic resection for pancreatic cancer.
• Its main advantage is the ability to locally deliver a high radiation dose, therefore boosting the effect of pre-op stereotactic body radiation therapy (SBRT).
• Here we report our initial experience with this treatment modality.
Methodology
• This is a retrospective review of patients who were at risk of not achieving satisfactory resection margins by surgery alone.
• They were treated with pre-operativeSBRT and neoadjuvant therapy.
• 2-4 weeks later patients underwent surgical intervention (Whipple, distal pancreatectomy).
• Immediately after resection IOeRT was delivered to a dose of 10-15 Gy at the tumor bed deemed at high risk for recurrence.
Read the findings>> here
