Dr. Joshua Moss

Dr. Joshua Moss, MD, PhD

  • Physician-researcher at the Sharrett Institute of Oncology at Hadassah Medical, Principal Investigator at the Hadassah Cancer Research Institute and Senior Lecturer at the Hebrew University of Jerusalem Israel.

    Dr. Moss’s research focuses on translational cancer biology, with an emphasis on circulating cell-free DNA and liquid biopsy technologies. Using computational and AI-based approaches combined with cutting-edge genomic approaches such as next-generation sequencing and nanopore sequencing, his lab studies DNA methylation and other DNA modification patterns to improve cancer detection, disease monitoring, and personalized treatment strategies.

    Dr. Moss integrates clinical oncology with data-driven research and collaborates closely with academic and industry partners to translate discoveries into clinical application.

  • In addition to his HCRI lab, Boaz leads the Hematology Department’s Clinical Flow Cytometry Unit at Hadassah, and is a senior lecturer on Hematology at the Faculty of Medicine. He earned a dual MD/PhD  from the Hebrew University of Jerusalem, including subspecialty fellowships in internal medicine and in hematology, and which was followed by a postdoctoral fellowship at the Princess Margaret Cancer Research Center, Toronto, Canada.
Recent Key publications
  • Chronic graft-versus-host disease detected by tissue-specific cell-free DNA methylation biomarkers. J Clin Inves. 2024 Jan 16;134(2):e163541. Batia Avni, Daniel Neiman, Elior Shaked, Ofer Gal-Rosenberg, Sigal Grisariu, Mona Kuzli, Ilai Avni, Andrea Fracchia, Polina Stepensky, Tsila Zuckerman, Ahinoam Lev-Sagie, Ilana Fox-Fisher, Sheina Piyanzin, Joshua Moss, Seth J Salpeter, Benjamin Glaser, Ruth Shemer, Yuval Dor.
  • Megakaryocyte-and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels. Nature communications. 2023 Nov 20;14(1):7542. Joshua Moss, Roni Ben-Ami, Ela Shai, Ofer Gal-Rosenberg, Yosef Kalish, Agnes Klochendler, Gordon Cann, Benjamin Glaser, Ariela Arad, Ruth Shemer, Yuval Dor.

  • A DNA methylation atlas of normal human cell types. 2023 Jan;613(7943):355-364. Netanel Loyfer , Judith Magenheim , Ayelet Peretz, Gordon Cann, Joerg Bredno, Agnes Klochendler, Ilana Fox-Fisher, Sapir Shabi-Porat, Merav Hecht , Tsuria Pelet, Joshua Moss, Zeina Drawshy, Hamed Amini Patriss Moradi , Sudharani Nagaraju , Dvora Bauman , David Shveiky, Shay Porat , Uri Dior , Gurion Rivkin, Omer Or , Nir Hirshoren , Einat Carmon , Alon Pikarsky, Abed Khalaileh, Gideon Zamir , Ronit Grinbaum , Machmud Abu Gazala, Ido Mizrahi, Noam Shussman , Amit Korach, Ori Wald , Uzi Izhar , Eldad Erez , Vladimir Yutkin , Yaacov Samet , Devorah Rotnemer Golinkin , Kirsty L Spalding , Henrik Druid , Peter Arner , A M James Shapiro , Markus Grompe , Alex Aravanis , Oliver Venn, Arash Jamshidi , Ruth Shemer , Yuval Dor , Benjamin Glaser , Tommy Kaplan.

  • Rapid Classification of Sarcomas Using Methylation Fingerprint: A Pilot Study. Cancers (Basel). 2023 Aug 18;15(16):4168. Aviel Iluz, Myriam Maoz, Nir Lavi, Hanna Charbit, Omer Or, Noam Olshinka, Jonathan Abraham Demma, Mohammad Adileh, Marc Wygoda, Philip Blumenfeld, Masha Gliner-Ron, Yusef Azraq, Joshua Moss, Tamar Peretz, Amir Eden, Aviad Zick, Iris Lavon.

  • Liquid biopsy reveals collateral tissue damage in cancer. JCI Insight. 2022 Jan 25;7(2):e153559. Asael Lubotzky, Hai Zemmour, Daniel Neiman, Marc Gotkine, Netanel Loyfer, Sheina Piyanzin , Bracha-Lea Ochana, Roni Lehmann-Werman, Daniel Cohen, Joshua Moss, Judith Magenheim, Maureen F Loftus, Lauren Brais, Kimmie Ng, Raul Mostoslavsky, Brian M Wolpin , Aviad Zick, Myriam Maoz, Albert Grinshpun, Anatoli Kustanovich, Chen Makranz, Jonathan E Cohen, Tamar Peretz, Ayala Hubert, Mark Temper, Azzam Salah, Shani Avniel-Polak , Simona Grozinsky-Glasberg, Kirsty L Spalding, Ariel Rokach, Tommy Kaplan, Benjamin Glaser, Ruth Shemer, Yuval Dor.

  • Remote immune processes revealed by immune-derived circulating cell-free DNA. eLife 2021 10:e70520. Ilana Fox-Fisher, Sheina Piyanzin, Bracha Lea Ochana, Agnes Klochendler, Judith Magenheim, Ayelet Peretz, Netanel Loyfer, Joshua Moss, Daniel Cohen, Yaron Drori, Nehemya Friedman, Michal Mandelboim, Marc E Rothenberg, Julie M Caldwell, Mark Rochman, Arash Jamshidi, Gordon Cann, David Lavi, Tommy Kaplan, Benjamin Glaser, Ruth Shemer, Yuval Dor.

  • Circulating breast-derived DNA allows universal detection and monitoring of localized breast cancer. Ann Oncol. 2020 Mar;31(3):395-403. J Moss, A Zick, A Grinshpun, E Carmon, M Maoz, BL Ochana, O Abraham, O Arieli, L Germansky, K Meir, B Glaser, R Shemer, B Uziely, Y Dor.

  • Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease. 2018 Nov  29;9(1):5068. Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, AM James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor.

  • Contribution of epigenetic mechanisms to variation in cancer risk among tissues. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2230-2234. Michael Klutstein, Joshua Moss, Tommy Kaplan, Howard Cedar.

  • Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. Roni Lehmann-Werman, Daniel Neiman, Hai Zemmour, Joshua Moss, Judith Magenheim, Adi Vaknin-Dembinsky, Sten Rubertsson, Bengt Nellgård, Kaj Blennow, Henrik Zetterberg, Kirsty Spalding, Michael J Haller, Clive H Wasserfall, Desmond A Schatz, Carla J Greenbaum, Craig Dorrell, Markus Grompe, Aviad Zick, Ayala Hubert, Myriam Maoz, Volker Fendrich, Detlef K Bartsch, Talia Golan, Shmuel A Ben Sasson, Gideon Zamir, Aharon Razin, Howard Cedar, AM James Shapiro, Benjamin Glaser, Ruth Shemer, Yuval Dor.