Adoptive Cell Therapy Using TCR

Adoptive Cell Therapy Using TCR-T Engineered Lymphocytes

Adoptive cell therapy, specifically TCR-T engineered lymphocytes against cancers, has emerged as a cutting-edge strategy in our therapeutic arsenal. In this process, T cells are taken from a patient, genetically engineered to express specific T Cell Receptors (TCRs) that can identify and bind to cancer cells, and then reintroduced into the patient’s body. 

Phase I/II study of adoptive cell therapy using TCR-T engineered lymphocytes against cancers expressing NYESO1 antigen

NY-ESO-1 - New York Esophageal Squamous Cell Carcinoma 1
  • NY-ESO-1 is a cancer testis antigen (CTA)
  • CTAs are immunogenic proteins displayed only by fetal and cancer cells
  • Expressed in deadly cancers: synovial sarcoma, uveal melanoma, triple negative breast cancer, ovarian cancer, neuroblastoma
NCT05296564 : Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes
Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers
  • Phase I and II, dose escalation and expansion
  • NY-ESO-1 expressing tumors, exhausted SOC
  • HLA A02:01 / A02:06
Our innovation
  • Improved design of the TCR backbone
  • Prevention of mispairing with endogenous TCR
  • Excellent target-peptide binding affinity and tumor killing
  • Cancer-agnostic approved protocol offered to any patient with
  • ESO-positive cancer

ESO Project Team

  • Prof. Michal Lotem - Principle Investigator​
  • Shiri Klein, PhD - Lead Scientist

Clinical Team

  • Prof. Aron Popovtzer​
  • Dr. Aviad Zick​​
  • Dr. Johnathan Arnon​
  • Dr. Yonatan Zarbiv ​​
  • Dr. Mordechai Avner ​

Scientific Collaboration

  • Prof. Cyrile Cohen​ - Bar Ilan University​
  • Prof. Nir Freidman​ - Hebrew University​

Bone Marrow Transplantation

  • Prof. Polina Stepensky ​
  • Dr. Batia Avni​
  • Dr. Sigal Grisariu​
  • Dr. Ana Elia - Pathologist
  • Dr. Nadia Kaplan​ - Radiologist
Technicians
  • Ina Ben-David​
  • Anna Kuznets​
  • Yael Gelfand​
Regulation
  • Inbal Fuchs​
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